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Cancer Answers is hosted by Dr. Anees Chagpar, Associate Professor of Surgical Oncology and Director of The Breast Center at Smilow Cancer Hospital at Yale-New Haven Hospital, and Dr. Francine Foss, Professor of Medical Oncology. The show features a guest cancer specialist who will share the most recent advances in cancer therapy and respond to listeners questions. Myths, facts and advances in cancer diagnosis and treatment are discussed, with a different focus eachweek. Nationally acclaimed specialists in various types of cancer research, diagnosis, and treatment discuss common misconceptions about the disease and respond to questions from the community.Listeners can submit questions to be answered on the program at canceranswers@yale.edu or by leaving a message at (888) 234-4YCC. As a resource, archived programs from 2006 through the present are available in both audio and written versions on the Yale Cancer Center website.

Lyme Disease Is On The Rise Again. Here's How To Prevent It

Black-legged ticks, also known as deer ticks, can carry Lyme disease.
Kenneth H Thomas
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Science Source/Getty Images
Black-legged ticks, also known as deer ticks, can carry Lyme disease.

Lyme disease was once unheard of in western Pennsylvania, where Barbara Thorne, now an entomologist at the University of Maryland, spent time as a kid.

Thorne knew that if black-legged ticks are infected with bacteria called Borrelia burgdorferi, they can transmit Lyme to people and, that if untreated, symptoms can range from fever, fatigue and a rash, to serious damage to the joints, heart and nervous system.

But she didn't realize that ticks in that part of Pennsylvania had become broadly infected with the bacteria. That is, until she was bitten during a family reunion weekend.

She never saw the tick on her body. But about eight or nine days later, after returning home, she became suspicious.

"I noticed a roundish red rash above my waistline and it expanded each day," she recalls. "I was also feeling sick with exhaustion and achiness."

Her primary care doctor diagnosed her with Lyme disease and prescribed a course of antibiotics. After a few months, she felt better.

"I felt very lucky to have had the rash appear as literally a red flag," Thorne says. It's a telltale warning sign of the disease.

But not everyone with a Lyme infection develops a rash. And other symptoms, such as fatigue and aches, overlap with common illnesses. So, spotting Lyme disease can be tricky. Some people don't realize they're infected and don't seek medical treatment.

The Centers for Disease Control and Prevention estimates the actual prevalence of Lyme disease infections is 10 times higher than the number of reported cases.

Tick-borne diseases have been "steadily going up every year ... as the diseases expand to new areas around the country," Lyle Peterson of the CDC told reporters in a recent conference call announcing the updated infection estimates. Lyme disease accounts for about 80 percent of the tick-borne illnesses in the U.S.

Another factor that can contribute to the underreporting of cases is a lack of effective surveillance and tracking.

"People just go to their local doctor to be treated," says Peterson, and the doctor may not report the case to the local or state health department. Or, if the case is reported by the doctor, he says, sometimes "state health departments have a very difficult time keeping up with the sheer number of cases reports."

There's another factor at play, too: shortcomings in the way the infection is diagnosed.

"Many of the tests for Lyme disease are negative at the time that patients first visit their doctor," says Dr. Paul Fiedler, a clinical pathologist on Yale School of Medicine's faculty who also heads the department of pathology at Western Connecticut Health Network.

Blood tests to detect Lyme disease rely on a person's immune response, Fiedler explains, and after infection with the bacteria, it takes time — sometimes as long as 10 to 30 days — for the body to mount a measurable response. The blood tests detect Lyme-specific antibodies.

If somebody is tested before the immune system has produced enough antibodies, the result will be a false negative.

"And the diagnosis could be missed," Fiedler says. The subsequent lack of treatment after a missed diagnosis can lead to serious health problems.

Black-legged ticks are small — the nymphs can be as little as the head of a pin, making them tough to spot.
Scott Camazine / Science Source/Getty Images
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Science Source/Getty Images
Black-legged ticks are small — the nymphs can be as little as the head of a pin, making them tough to spot.

But Thorne says it's possible to take steps to help prevent Lyme disease if you're meticulous.

In the spring, tick nymphs — young versions that transmit most of the Lyme infections — are abundant. They're tiny, no bigger than a pinhead or poppy seed, and tend to hang out in or near wooded areas, in brush or tall grass.

The ticks need a blood meal to stay alive. They tend to feedon small mammals, such as mice, or birds. But if you happen to brush against a stick, blade or stem they're clinging to, they can easily hitch a ride on you. And you won't feel a thing.

If you're hiking in or near a wooded area, it's wise to be on the lookout for nymphs on your skin or clothing when you get home. "They're small, but they're not invisible," Thorne says.

She recommends light-colored clothing (to increase likelihood you'll notice the darker fleck of an insect) and long sleeves. Insect repellent may help, but Thorne says the most effective strategy is a thorough tick check of your body after you've been in tick-infested areas.

"The ticks do tend to climb upward — like they climb up your legs," Thorne says. "They often attach where there was a constriction of clothing, like around the waistline." (She's compiled personal protection tips in this bulletin.)

Other favorite hiding spots include armpits, or behind your ears. If you do find one attached to your body, use a pair of narrow tweezers to grasp the tick very near the surface of the skin and tug upward with steady pressure.

Don't freak out if the arachnid's been attached a few hours. In general, the CDC says, ticks need to be attached for 36 to 48 hours before they can transmit the bacteria that cause Lyme disease.

Copyright 2021 NPR. To see more, visit https://www.npr.org.

Allison Aubrey is a correspondent for NPR News, where her stories can be heard on Morning Edition and All Things Considered. She's also a contributor to the PBS NewsHour and is one of the hosts of NPR's Life Kit.

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