In 2003, Jay Siegel was up for a new challenge. Siegel was a tenured professor of chemistry at the University of California, San Diego, but he took a job at the University of Zurich.
"When I first moved, people said, 'Oh, you're crazy to leave San Diego; it's a paradise. Why would you go to Europe? Blah, blah blah,' "recalls Siegel. "And after 10 years people were saying, 'Oh, man, that was the smartest thing you ever did. Zurich is wonderful.' "